Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Allyl chloroformate → 3beta-Carboallyloxyandrost-5-ene-7,17-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Allyl chloroformate | HCID 18052 | — |
| 반응물 | 7-Keto-dehydroepiandrosterone | HCID 193313 | — |
| 용매 | Pyridine tetrahydrofuran | HCID 16069498 | — |
| 생성물 | 3beta-Carboallyloxyandrost-5-ene-7,17-dione | HCID 10237228 | 78% |
반응 단계
Compound 43 was prepared from 7-oxo-DHEA (2) (1.0 mmol) and allylchloroformate (4.0 mmol) in tetrahydrofuran-pyridine mixture at 0-5° C. After stirring 6 hours only 30% conversion had occurred; from the mixture the product was isolated in 78% yield (based on 30% conversion) by column chromatography. M.p. 159-61° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07947846B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-6f73282656b34cddbebf95d4a3db0422 |
| 출처 메모 | uspto-grants-2011_05 |