1-Butanol → 1-(Dibutoxymethyl)-2-nitrobenzene

HRID 552074노트

반응식

HRID 552074 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]=[O:7])([O-:3])=[O:2].[CH2:12]([OH:16])[CH2:13][CH2:14][CH3:15].O.[C:18]1(C)[CH:23]=CC(S(O)(=O)=O)=[CH:20][CH:19]=1>C1(C)C=CC=CC=1>[CH2:23]([O:7][CH:6]([O:16][CH2:12][CH2:13][CH2:14][CH3:15])[C:5]1[CH:8]=[CH:9][CH:10]=[CH:11][C:4]=1[N+:1]([O-:3])=[O:2])[CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 2631-ButanolHCID 111012-NitrobenzaldehydeHCID 521998p-Toluenesulfonic acid monohydrate

생성물 1

HCID 150331791-(Dibutoxymethyl)-2-nitrobenzene

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution comprising 2-nitrobenzaldehyde (4.53 g, 30.0 mmol), 1-butanol (13.7 ml, 150 mmol) and toluene (60 ml) was added with p-toluene sulfonic acid monohydrate (57 mg, 0.300 mmol) and molecular sieves-4A (1 g), and refluxed for two days. The mixture was filtered through celite, washed with saturated sodium bicarbonate and saturated sodium chloride water, and then dried with anhydrous magnesium sulfate. The solution was concentrated to obtain Step 1 compound (8.43 g, quant) as a brown oily substance.

후처리

  1. temperaturerefluxed for two days
  2. filtrationThe mixture was filtered through celite
  3. washwashed with saturated sodium bicarbonate and saturated sodium chloride water
  4. dry with materialdried with anhydrous magnesium sulfate
  5. concentrationThe solution was concentrated
  6. customto obtain Step 1 compound (8.43 g, quant) as a brown oily substance

출처 및 근거

ORD 기록
ord-b870e373095c4260958f2cae81581c84
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951799B2

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