Trifluoroacetic acid → L-Valyl-L-valine

HRID 552078노트

반응식

HRID 552078 반응식
[CH3:1][CH:2]([C@H:4]([NH:8][C:9]([O:11]C(C)(C)C)=O)[C:5]([OH:7])=[O:6])[CH3:3].C1CCC(N=C=NC2CCCCC2)CC1.C(O)(C(F)(F)F)=O.[CH3:38][CH:39]([C@H:41]([NH2:60])C(OCCOCN1C2NC(N)=NC(=O)C=2N=C1)=O)[CH3:40]>CN(C1C=CN=CC=1)C.CN(C=O)C>[CH3:38][CH:39]([C@H:41]([NH2:60])[C:9]([NH:8][C@H:4]([C:5]([OH:7])=[O:6])[CH:2]([CH3:1])[CH3:3])=[O:11])[CH3:40]

참가 물질

7

반응물 4

HCID 6422Trifluoroacetic acid2회HCID 10868Dicyclohexylcarbodiimide2회HCID 83693Boc-L-Valine2회HCID 178448382HCID 178448382, 화합물

생성물 1

HCID 107475L-Valyl-L-valine

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6228Dimethylformamide용매3회

실험 절차

Boc-VAL, DCC, DMF, 0° C., 1 hr, ii) DMAP, DMF, 18 hrs, rt iii) TFA, 0° C., 30 min, iv) Boc-Val, DCC, DMF, 0° C., 1 hr, v) TEA, rt, vi) adding Boc-Val amino acid anhydride (step iv) to the neutralized Val-ACV (step v), 5 hrs, rt, vii) TFA, 0° C., 30 min.

출처 및 근거

ORD 기록
ord-17b1a54e57d1442fb549714abb81c98a
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951774B2

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