Hydrochloric Acid → 2-Aminopyrimidine-4-carbaldehyde

HRID 552114노트

반응식

HRID 552114 반응식
C[O:2][CH:3](OC)[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH2:10])[N:5]=1.Cl.C([O-])(O)=O.[Na+]>CCOC(C)=O>[NH2:10][C:6]1[N:5]=[C:4]([CH:3]=[O:2])[CH:9]=[CH:8][N:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 49130324-(dimethoxymethyl)pyrimidin-2-amine

생성물 1

HCID 178323462-Aminopyrimidine-4-carbaldehyde수율 37.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2.5 g (15 mmol, 1.0 eq.) of 2-aminopyrimidine-4-carboxaldehyde dimethylacetal (I-8) in 16 mL (48 mmol, 3.2 eq.) of 3M HCl was heated at 48° C. for 14 h. The mixture was allowed to cool to room temperature and diluted with 50 mL of EtOAc. The aqueous layer was neutralized with NaHCO3 and then extracted with EtOAc (5×50 mL). The combined organic extracts were dried (Na2SO4) and the solvent removed in vacuo to provide 0.69 g (5.6 mmol, 37%) of 2-aminopyrimidine-4-carboxaldehyde (I-9) as a yellow solid.

후처리

  1. extractionextracted with EtOAc (5×50 mL)
  2. dry with materialThe combined organic extracts were dried (Na2SO4)
  3. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-8d1c69c2c51a44118c5950aa007bf96e
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951803B2

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