56222-10-7 → N-[(4-aminophenyl)methyl]acetamide

HRID 552121노트

반응식

HRID 552121 반응식
[N+:1]([C:4]1[CH:14]=[CH:13][C:7]([CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C1COCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 4178456222-10-7HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 228286N-[(4-aminophenyl)methyl]acetamide수율 100%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4.0 g (21 mmol, 1.0 eq.) of N-(4-nitrobenzyl)acetamide (I-21) in 100 mL of THF was added a catalytic amount of Raney Nickel. The mixture was stirred under 1 atm. of hydrogen at room temperature for 16 h. The mixture was filtered through Celite® and the pad was washed with 100 mL of THF. The solvent was removed in vacuo to provide 3.4 g (21 mmol, 100%) of N-(4-aminobenzyl)acetamide (I-22).

후처리

  1. filtrationThe mixture was filtered through Celite®
  2. washthe pad was washed with 100 mL of THF
  3. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-146d079e255f45ee93e4a7ebdedac062
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951803B2

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