Hydrogen Bromide → 4-Bromo-6-methylpyridine-2-carboxylic acid

HRID 552483노트

반응식

HRID 552483 반응식
[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([N+]([O-])=O)[CH:3]=1.[BrH:14]>>[Br:14][C:4]1[CH:3]=[C:2]([CH3:1])[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 112753916-methyl-4-nitropicolinic acid

생성물 1

HCID 534852954-Bromo-6-methylpyridine-2-carboxylic acid

실험 절차

A solution of 3.6 g (19.6 mmol) of 6-Methyl-4-nitro-pyridine-2-carboxylic acid in 40 ml of 48% hydrobromic acid was heated at 100° C. overnight and then allowed to cool to room temperature. The solution was then evaporated to dryness in vaccuo. The crude material (10.5 g) containing inorganic salts was directly used in the next step.

후처리

  1. customThe solution was then evaporated to dryness in vaccuo
  2. additionThe crude material (10.5 g) containing inorganic salts

출처 및 근거

ORD 기록
ord-7534d19fc07f4379a371d23045f25060
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951824B2

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