Phosphorus oxychloride → 4-Thiazoleacetonitrile, 2-amino-
반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH2:10])=O)[N:6]=1.P(Cl)(Cl)(Cl)=O>CN(C=O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]#[N:10])[N:6]=1참가 물질
4
실험 절차
To a solution of 2.0 g (13.0 mmol) of 2-(2-Amino-thiazol-4-yl)-acetamide in 30 ml of dry DMF was added Phosphorus oxychloride (2.3 ml, 25.0 mmol, 2.0 equiv.) dropwise at 0° C.
출처 및 근거
- ORD 기록
- ord-96323deaafd94ef2a0bb7a3f45f00494
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07951824B2
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