Dimethylformamide dimethyl acetal → 4-Bromo-N-[(dimethylamino)methylene]-2-methylbenzamide

HRID 552662노트

반응식

HRID 552662 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[C:4]([CH3:11])[CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[CH:14][N:15]([CH3:17])[CH3:16])=[O:7])=[C:4]([CH3:11])[CH:3]=1

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 206167664-Bromo-2-methylbenzamide

생성물 1

HCID 666997874-Bromo-N-[(dimethylamino)methylene]-2-methylbenzamide

반응 조건

온도
70 °C

실험 절차

A mixture of 0.84 g of 4-bromo-2-methyl benzoic acid amide and 18 mL of N,N-dimethylformamide dimethylacetal was stirred at 70° C. for 30 minutes. After the completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was washed with 5 mL of hexane to obtain 0.67 g of the aimed product as white crystal.

후처리

  1. customAfter the completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. washthe residue was washed with 5 mL of hexane

출처 및 근거

ORD 기록
ord-fb987175a0e64a83997d709c59d86460
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951828B1

반응 노트

불러오는 중…