[OH-].[Li+].C[O:4][C:5](=[O:29])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]3[CH2:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:21]3)[CH:14]=2)=[CH:9][CH:8]=1.C(O)(=O)C>O.O1CCCC1>[CH2:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:28][N:20]1[CH2:19][C:15]1[CH:14]=[C:13]([C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C:5]([OH:29])=[O:4])=[CH:12][CH:11]=2)[CH:18]=[CH:17][CH:16]=1Lithium hydroxide (126 mg) in water (5 mL) was added to a solution of [3′-(1,3-dihydro-iso-indol-2-ylmethyl)-biphenyl-4-yl]-acetic acid methyl ester (0.47 g) in tetrahydrofuran (10 mL) and stirred at room temperature for 72 hour. The reaction mixture was acidified with glacial acetic acid and evaporated. The residue was partitioned between ethyl acetate (20 mL) and water (20 mL). The aqueous was separated and extracted with ethyl acetate (2×20 mL). The combined organics were washed with brine (20 mL), dried (sodium sulfate) and evaporated to give a the subtitle compound as a brown oil (450 mg).
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