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1-[2-[4-(2-Methoxycarbonyl-2-methylpropyl)phenyl]ethyl]-1,5-diazacyclooctane → 1-[1-(4-chlorophenylmethyl)-1H-benzimidazol-2-yl]-5-[2-[4-(2-methoxycarbonyl-2-methylpropyl)phenyl]ethyl]-1,5-diazacyclooctane

HRID 55331
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HRID 55331 반응식
Br[C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N:3]=1.[CH3:19][O:20][C:21]([C:23]([CH3:42])([CH3:41])[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][N:33]2[CH2:40][CH2:39][CH2:38][NH:37][CH2:36][CH2:35][CH2:34]2)=[CH:27][CH:26]=1)=[O:22]>C(O)CCC>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][N:6]2[C:5]3[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=3[N:3]=[C:2]2[N:37]2[CH2:38][CH2:39][CH2:40][N:33]([CH2:32][CH2:31][C:28]3[CH:29]=[CH:30][C:25]([CH2:24][C:23]([C:21]([O:20][CH3:19])=[O:22])([CH3:42])[CH3:41])=[CH:26][CH:27]=3)[CH2:34][CH2:35][CH2:36]2)=[CH:9][CH:10]=1
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참가 물질

4

반응물 2

HCID 199575131-[2-[4-(2-Methoxycarbonyl-2-methylpropyl)phenyl]ethyl]-1,5-diazacyclooctaneHCID 199575172-bromo-1-(4-chlorophenylmethyl)-1H-benzimidazole

생성물 1

HCID 199575141-[1-(4-chlorophenylmethyl)-1H-benzimidazol-2-yl]-5-[2-[4-(2-methoxycarbonyl-2-methylpropyl)phenyl]ethyl]-1,5-diazacyclooctane수율 58%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

To a solution of 2-bromo-1-(4-chlorophenylmethyl)-1H-benzimidazole (0.029 g) in n-butanol (0.5 ml) was added 1-[2-[4-(2-methoxycarbonyl-2-methylpropyl)phenyl]ethyl]-1,5-diazacyclooctane (0.102 g), and the mixture was refluxed for 3 hours. The reaction mixture was quenched with a saturated aqueous NaHCO3 solution (30 ml), and the mixture was extracted with methylene chloride (20 ml). The extract was washed with water, and dried over anhydrous MgSO4. The solvent was removed under reduced pressure, and the residue was purified by medium pressure liquid column chromatography on a silica gel column using a mixture of methylene chloride, diethyl ether and methanol (1:1:0.2) as eluent to give 1-[1-(4-chlorophenylmethyl)-1H-benzimidazol-2-yl]-5-[2-[4-(2-methoxycarbonyl-2-methylpropyl)phenyl]ethyl]-1,5-diazacyclooctane (0.030 g) as a colorless oily liquid.

후처리

  1. temperaturethe mixture was refluxed for 3 hours
  2. customThe reaction mixture was quenched with a saturated aqueous NaHCO3 solution (30 ml)
  3. extractionthe mixture was extracted with methylene chloride (20 ml)
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous MgSO4
  6. customThe solvent was removed under reduced pressure
  7. customthe residue was purified by medium pressure liquid column chromatography on a silica gel column
  8. additiona mixture of methylene chloride, diethyl ether and methanol (1:1:0.2) as eluent

출처 및 근거

ORD 기록
ord-e73b6b9de0744504bd3c6e59ec7f1560
출처 데이터셋
uspto-grants-1997_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05624948

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