Ethylenediamine → 1,3-Bis-(2-methoxy-5-trifluoromethoxybenzyl)imidazolidin-2-ylideneamine
반응식
[CH2:1]([NH2:4])[CH2:2][NH2:3].[CH3:5][O:6][C:7]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][C:8]=1[C:9](Cl)=O.[C:21](#[N:23])C>>[CH3:5][O:6][C:7]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][C:8]=1[CH2:9][N:3]1[CH2:2][CH2:1][N:4]([CH2:9][C:8]2[CH:12]=[C:13]([O:16][C:17]([F:18])([F:19])[F:20])[CH:14]=[CH:15][C:7]=2[O:6][CH3:5])[C:21]1=[NH:23]참가 물질
4
실험 절차
The title compound was prepared in three steps as described in Procedure D. In the first step, ethylenediamine was reacted in acetonitrile with 2-methoxy-5-(trifluoromethoxy)benzoylchloride (2 eq) in the presence of TEA to give the dibenzoylated ethylenediamine upon aqueous work-up. After the last step (reaction with cyanogen bromide), the crude product was isolated upon aqueous work-up and purified by column chromatography to give the title compound as the hydrogen bromide salt. MS (ES+) m/z 494 ([M+1]+, 100); HR-MS: 494.1532 ([M+1]+, C21H22F8N3O4; calc. 494.15145).
출처 및 근거
- ORD 기록
- ord-17dfb748238548dabc9e9fd148fe05ca
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08048877B2
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