Ammonium Hydroxide → HCID 57924582, 화합물

반응식

[CH:1]([N:4]1[C:8]2[CH:9]=[N:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]1=O)([CH3:3])[CH3:2].[NH4+].[OH-].O=P(Cl)(Cl)[Cl:18]>>[Cl:18][C:5]1[N:4]([CH:1]([CH3:3])[CH3:2])[C:8]2[CH:9]=[N:10][CH:11]=[CH:12][C:7]=2[N:6]=1

참가 물질

반응물 3

HCID 14923Ammonium Hydroxide

HCID 24813Phosphorus oxychloride

HCID 21822966HCID 21822966, 화합물

생성물 1

HCID 57924582HCID 57924582, 화합물

실험 절차

A mixture of 3-isopropyl-1H-imidazo[4,5-c]pyridin-2(3H)-one (0.5 g, 2.82 mmol.) in POCl3 (5 mL) was refluxed for 16 hrs. Then the reaction mixture was poured into ice water and basified with NH4OH to pH=7˜8. The mixture was extracted with ethyl acetate. The organic layer was dried over Na2SO4 and evaporated to afford crude 2-chloro-3-isopropyl-3H-imidazo[4,5-c]pyridine which was used directly for the next step (150 mg, 27%).