Phosphorus oxychloride → Ethyl (chlorosulfonyl)acetate

HRID 553463

반응식

HRID 553463 반응식
[CH2:1]([O:3][C:4]([CH2:6][S:7]([OH:10])(=O)=[O:8])=[O:5])[CH3:2].O=P(Cl)(Cl)[Cl:13]>>[CH2:1]([O:3][C:4]([CH2:6][S:7]([Cl:13])(=[O:10])=[O:8])=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 12216623Ethyl sulfoacetate

생성물 1

HCID 12225100Ethyl (chlorosulfonyl)acetate수율 80%

반응 조건

온도
125 °C

실험 절차

A mixture of (ethoxycarbonyl)methanesulfonic acid (10 g, 60 mmol.) and POCl3 (45 mL) was heated at 125° C. for 5 h. The mixture was cooled and filtered, and excess POCl3 was removed to give crude (ethoxycarbonyl)methanesulfonyl chloride (8.1 g, 80%) used directly without purification.

후처리

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. customexcess POCl3 was removed

출처 및 근거

ORD 기록
ord-145e8909bddf407fb3c521a421fdb0af
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048862B2

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