참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tert-Butylamine | HCID 6385 | — |
| 반응물 | Ethyl (chlorosulfonyl)acetate | HCID 12225100 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | ethyl-2-(N-tert-butylsulfamoyl)acetate | HCID 19833529 | 43% |
반응 단계
tert-Butylamine (7.9 mL, 75 mmol.) was dissolved in 50 mL of THF. The solution was cooled to −20° C. and (ethoxycarbonyl)methanesulfonyl chloride dissolved in 10 mL of THF was added slowly. The reaction mixture was allowed to warm to room temperature and stirred for 24 h. The mixture was filtered, and the filtrate concentrated in vacuo. The residue was purified by column chromatography (PE/EtOAc; 2:1) to afford ethyl-2-(N-tert-butylsulfamoyl)acetate (4.1 g, 43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08048862B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-794c0450771447b48a4f95417416d507 |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
