反应详情

温度

-20 °C

tert-Butylamine (7.9 mL, 75 mmol.) was dissolved in 50 mL of THF. The solution was cooled to −20° C. and (ethoxycarbonyl)methanesulfonyl chloride dissolved in 10 mL of THF was added slowly. The reaction mixture was allowed to warm to room temperature and stirred for 24 h. The mixture was filtered, and the filtrate concentrated in vacuo. The residue was purified by column chromatography (PE/EtOAc; 2:1) to afford ethyl-2-(N-tert-butylsulfamoyl)acetate (4.1 g, 43%).

1. additionwas added slowly
2. temperatureto warm to room temperature
3. filtrationThe mixture was filtered
4. concentrationthe filtrate concentrated in vacuo
5. customThe residue was purified by column chromatography (PE/EtOAc; 2:1)