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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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HCID 44596871, 화합물 → HCID 13876050, 화합물

HRID 553557
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HRID 553557 반응식
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][C@:8]2([CH3:28])[C:12](=[O:13])[O:11][C@@H](C3C=CC=CC=3)[N:9]2C(C2C=CC=CC=2)=O)=[CH:5][CH:4]=1>Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][C@:8]([CH3:28])([C:12]([OH:13])=[O:11])[NH2:9])=[CH:29][CH:30]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

3

반응물 1

HCID 44596871HCID 44596871, 화합물

생성물 1

HCID 13876050HCID 13876050, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Compound 2.3 (2.2 g, 0.0055 mol) were suspended in 20 mL of concentrated HCl solution. After nitrogen flush, the mixture was heated under reflux for 3 hours. After filtration and removal of the HCl solution, the white precipitate was dried. 1H NMR δ 7.24 (d, 2H, J=6 Hz), 6.91 (d, 2H, J=6 Hz), 3.77 (3H, s), 3.26 (d, 1H, J=14 Hz), 3.13 (d, 1H, J=14 Hz), 1.66 (s, 3H); C NMR 173.8, 161.3, 132.9, 115.9, 62.4, 56.4, 43.5, 23.2; ESI MS 210 (M+1). The product was used in the next step without purification.

후처리

  1. customAfter nitrogen flush
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 3 hours
  4. filtrationAfter filtration and removal of the HCl solution
  5. customthe white precipitate was dried
  6. customThe product was used in the next step without purification

출처 및 근거

ORD 기록
ord-6d7e6fc4cc314556bf2c78b86844bfff
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08048895B2

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