Methylamine → Methyl 3-(methylamino)but-2-enoate

HRID 553660

반응식

HRID 553660 반응식
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:9][NH2:10]>CO>[CH3:8][O:7][C:1](=[O:6])[CH:2]=[C:3]([NH:10][CH3:9])[CH3:5]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 7757Methyl acetoacetate

생성물 1

HCID 2734182Methyl 3-(methylamino)but-2-enoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl acetoacetate (29.4 g, 253 mmol) in methanol (30 mL) was added methylamine (33 wt % in EtOH; 48 mL, 385 mmol) dropwise at room temperature. The reaction was stirred for 1 hour, and then concentrated and dried to give the title compound as a white crystalline solid.

후처리

  1. concentrationconcentrated
  2. customdried

출처 및 근거

ORD 기록
ord-c5a35a4b1c7944b1a0650f2da778ae9e
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048902B2

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