Potassium Phosphate, Tribasic → Methyl 6-methyl-2-phenyl-4-pyrimidinecarboxylate

HRID 553826

반응식

HRID 553826 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7](Cl)[N:6]=1)=[O:4].[C:13]1(B(O)O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].O.CC(=O)OCC>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)=[O:4]

참가 물질

7

반응물 4

HCID 62657Potassium Phosphate, TribasicHCID 66827Phenylboronic AcidHCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylateHCID 22728543Water ethylacetate

생성물 1

HCID 58101529Methyl 6-methyl-2-phenyl-4-pyrimidinecarboxylate

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 312751,4-Dioxane용매

실험 절차

2-chloro-6-methyl-pyrimidine-4-carboxylic acid methyl ester (930 mg), phenylboronic acid (610 mg), tetrakis(triphenylphosphine)palladium (265 mg) and potassium phosphate (2.12 g) were dissolved in anhydrous dioxane (25 ml) under argon. The mixture was refluxed overnight and worked up with water/EA. The org. phases were dried (Na2SO4) and evaporated off. Column chromatography (EA/Hept 1/5) offered 875 mg of the desired compound.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. dry with materialphases were dried (Na2SO4)
  3. customevaporated off

출처 및 근거

ORD 기록
ord-99a308eb50b24b91a6980a55a346e494
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048881B2

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