Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Phosphate, Tribasic → Methyl 6-methyl-2-phenylpyrimidine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | Methyl 2-chloro-6-methylpyrimidine-4-carboxylate | HCID 2736835 | — |
| 반응물 | Water ethylacetate | HCID 22728543 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Methyl 6-methyl-2-phenylpyrimidine-4-carboxylate | HCID 58101529 | — |
반응 단계
2-chloro-6-methyl-pyrimidine-4-carboxylic acid methyl ester (930 mg), phenylboronic acid (610 mg), tetrakis(triphenylphosphine)palladium (265 mg) and potassium phosphate (2.12 g) were dissolved in anhydrous dioxane (25 ml) under argon. The mixture was refluxed overnight and worked up with water/EA. The org. phases were dried (Na2SO4) and evaporated off. Column chromatography (EA/Hept 1/5) offered 875 mg of the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048881B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-99a308eb50b24b91a6980a55a346e494 |
| 출처 메모 | uspto-grants-2011_11 |