Triethyl phosphite → diethyl[(4R*,10aS*)-4-(4-fluorophenyl)-6-oxodecahydropyrido[1,2-a]azepin-7-yl]phosphonate

HRID 553887노트

반응식

HRID 553887 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:13]3[C:14](=[O:20])[CH:15](I)[CH2:16][CH2:17][CH2:18][C@@H:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[P:21]([O:28]CC)([O:25][CH2:26][CH3:27])[O:22][CH2:23][CH3:24]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:13]3[C:14](=[O:20])[CH:15]([P:21](=[O:28])([O:25][CH2:26][CH3:27])[O:22][CH2:23][CH3:24])[CH2:16][CH2:17][CH2:18][C@@H:12]3[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 31215Triethyl phosphiteHCID 69070104(4R*,10aS*)-4-(4-fluorophenyl)-7-iodooctahydropyrido[1,2-a]azepin-6-one

생성물 1

HCID 86612698diethyl[(4R*,10aS*)-4-(4-fluorophenyl)-6-oxodecahydropyrido[1,2-a]azepin-7-yl]phosphonate

반응 조건

온도
120 °C

실험 절차

A mixture of (4R*,10aS*)-4-(4-fluorophenyl)-7-iodooctahydropyrido[1,2-a]azepin-6-one (208 mg) with triethyl phosphite (2 mL) was stirred at 120° C. for 1.5 hours. The reaction solution was left to cool to room temperature and then concentrated under reduced pressure to obtain 213 mg of the title compound. The property value of the compound is as follows.

후처리

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c32d133a0baa444a9aa5c784e0d09e54
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048878B2

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