Triethyl phosphite → diethyl[(6S*,9aR*)-6-(3-fluorophenyl)-4-oxooctahydroquinolizin-3-yl]phosphonate

HRID 553907노트

반응식

HRID 553907 반응식
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:17][CH2:16][CH2:15][C@@H:14]3[N:9]2[C:10](=[O:19])[CH:11](I)[CH2:12][CH2:13]3)[CH:5]=[CH:6][CH:7]=1.[P:20]([O:27]CC)([O:24][CH2:25][CH3:26])[O:21][CH2:22][CH3:23]>>[F:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[CH2:17][CH2:16][CH2:15][C@H:14]3[N:9]2[C:10](=[O:19])[CH:11]([P:20](=[O:27])([O:24][CH2:25][CH3:26])[O:21][CH2:22][CH3:23])[CH2:12][CH2:13]3)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 31215Triethyl phosphiteHCID 69075941(6R*,9aS*)-6-(3-fluorophenyl)-3-iodooctahydroquinolizin-4-one

생성물 1

HCID 86612701diethyl[(6S*,9aR*)-6-(3-fluorophenyl)-4-oxooctahydroquinolizin-3-yl]phosphonate

반응 조건

온도
120 °C

실험 절차

A mixture of (6R*,9aS*)-6-(3-fluorophenyl)-3-iodooctahydroquinolizin-4-one (597 mg) with triethyl phosphite (6 mL) was stirred at 120° C. for five hours. The reaction solution was left to cool to room temperature and then concentrated under reduced pressure to obtain 670 mg of the title compound. The property value of the compound is as follows.

후처리

  1. waitThe reaction solution was left
  2. temperatureto cool to room temperature
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7f1632ed833e41e788419ba545947c6a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048878B2

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