Tosylmethyl isocyanide → Ethyl 4-methyl-1h-pyrrole-3-carboxylate

HRID 554186

반응식

C1(C)C=CC(S([CH2:10][N+:11]#[C-:12])(=O)=O)=CC=1.[C:14]([O:19][CH2:20][CH3:21])(=[O:18])/[CH:15]=[CH:16]/[CH3:17].CC(C)([O-])C.[K+]>>[CH3:17][C:16]1[C:15]([C:14]([O:19][CH2:20][CH3:21])=[O:18])=[CH:10][NH:11][CH:12]=1

참가 물질

반응물 3

HCID 161915Tosylmethyl isocyanide

HCID 429065Ethyl trans-crotonate

HCID 23665647Potassium tert-butoxide

생성물 1

HCID 235044Ethyl 4-methyl-1h-pyrrole-3-carboxylate수율 71.1%

실험 절차

Using p-toluenesulfonylmethyl isocyanide (8.55 g), ethyl crotonate (5.0 g) and potassium tert-butoxide (5.90 g), a procedure as in Reference Example 39 was performed to give the title compound as a pale-yellow solid (yield 4.77 g, 71%).

출처 및 근거

ORD 기록: ord-c31a5c841b6e47ee8805ad48720a6c35
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08048909B2

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