N-bromobutanimide → Methyl 5-bromo-4-methyl-1H-pyrrole-3-carboxylate

HRID 554231노트

반응식

[CH3:1][C:2]1[C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][NH:5][CH:6]=1.[Br:11]N1C(=O)CCC1=O>>[Br:11][C:6]1[NH:5][CH:4]=[C:3]([C:7]([O:9][CH3:10])=[O:8])[C:2]=1[CH3:1]

참가 물질

반응물 2

HCID 67184N-bromobutanimide

HCID 15274278Methyl 4-methyl-1H-pyrrole-3-carboxylate

생성물 1

HCID 66924763Methyl 5-bromo-4-methyl-1H-pyrrole-3-carboxylate

실험 절차

By a similar operation as in Reference Example 40 and using methyl 4-methyl-1H-pyrrole-3-carboxylate (1.0 g) and N-bromosuccinimide (1.28 g), the title compound was obtained as a pale-yellow solid (yield 489 mg, 31%).

출처 및 근거

ORD 기록: ord-3f0821fc31904e96ab4c344d1aee205d
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08048909B2

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