Methyl morpholine oxide → 5-Bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

HRID 554299노트

반응식

HRID 554299 반응식
[Br:1][C:2]1[N:6]([S:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:5]=[C:4]([CH2:16][OH:17])[C:3]=1[CH2:18][CH3:19].C[N+]1([O-])CCOCC1>[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[N:6]([S:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:5]=[C:4]([CH:16]=[O:17])[C:3]=1[CH2:18][CH3:19]

참가 물질

4

반응물 2

HCID 82029Methyl morpholine oxideHCID 66924674[5-Bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol

생성물 1

HCID 862328285-Bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde수율 49%

시약·촉매·용매 1

HCID 178419074HCID 178419074, 화합물촉매

실험 절차

Using [5-bromo-4-ethyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol (1.05 g), tetra-n-propylammonium perruthenate (54.3 mg), N-methylmorpholine N-oxide (543 mg) and molecular sieves 4A powder (522 mg), a procedure as in Reference Example 6 was performed to give the title compound as white crystals (yield 0.51 g, 49%).

출처 및 근거

ORD 기록
ord-a4d338d02ec44315b0eb2a71ffbfbaf4
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048909B2

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