Sodium hydride → Methyl 3-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate

HRID 554320노트

반응식

HRID 554320 반응식
[C:1]1([C:7]2[NH:11][CH:10]=[C:9]([CH:12]=[O:13])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].C1OCCOCCOCCOCCOC1.Cl[S:32]([C:35]1[CH:36]=[C:37]([CH:42]=[CH:43][CH:44]=1)[C:38]([O:40][CH3:41])=[O:39])(=[O:34])=[O:33]>>[CH:12]([C:9]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:11]([S:32]([C:35]2[CH:36]=[C:37]([CH:42]=[CH:43][CH:44]=2)[C:38]([O:40][CH3:41])=[O:39])(=[O:34])=[O:33])[CH:10]=1)=[O:13]

참가 물질

5

반응물 4

HCID 24758Sodium hydrideHCID 3633615-Crown-5HCID 113339Benzoic acid, 3-(chlorosulfonyl)-, methyl esterHCID 110520905-Phenyl-1H-pyrrole-3-carboxaldehyde

생성물 1

HCID 86620754Methyl 3-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate수율 69%

실험 절차

Using 5-phenyl-1H-pyrrole-3-carbaldehyde (1.32 g), sodium hydride (60% in oil, 444 mg), 15-crown-5 (2.04 g) and methyl 3-(chlorosulfonyl)benzoate (2.17 g), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow oil (yield 1.96 g, 69%).

출처 및 근거

ORD 기록
ord-61c2192d8a1a4e19a88fc7d0c6e0b23a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048909B2

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