Sodium hydride → 1-[(2,5-Dimethoxyphenyl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde

HRID 554335노트

반응식

HRID 554335 반응식
[CH3:1][C:2]1[C:3]([CH:13]=[O:14])=[CH:4][NH:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[H-].[Na+].C1OCCOCCOCCOCCOC1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][C:35]=1[S:42](Cl)(=[O:44])=[O:43]>>[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][C:35]=1[S:42]([N:5]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:2]([CH3:1])[C:3]([CH:13]=[O:14])=[CH:4]1)(=[O:43])=[O:44]

참가 물질

5

반응물 4

HCID 24758Sodium hydrideHCID 3633615-Crown-5HCID 1370252,5-Dimethoxybenzenesulfonyl chlorideHCID 713628124-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde

생성물 1

HCID 866207631-[(2,5-Dimethoxyphenyl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde수율 86%

실험 절차

Using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 72 mg), 15-crown-5 (330 mg) and 2,5-dimethoxybenzenesulfonyl chloride (355 mg), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow powder (yield 330 mg, 86%).

출처 및 근거

ORD 기록
ord-a4ba13949b4e4b498ee9ec7183991f53
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048909B2

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