Sodium hydride → 1-{1-[(3-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride

HRID 554406노트

반응식

HRID 554406 반응식
C[N:2]([CH2:10][C:11]1[CH:15]=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[NH:13][CH:12]=1)[C:3](=O)OC(C)(C)C.[H-].[Na+].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([S:32]([Cl:35])(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1>>[ClH:35].[CH3:24][O:25][C:26]1[CH:27]=[C:28]([S:32]([N:13]2[C:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:15][C:11]([CH2:10][NH:2][CH3:3])=[CH:12]2)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 27375043-Methoxybenzenesulfonyl chlorideHCID 57522146Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate

생성물 1

HCID 575221431-{1-[(3-Methoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine hydrochloride수율 68%

실험 절차

Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (200 mg), sodium hydride (60% in oil, 140 mg) and 3-methoxybenzenesulfonyl chloride (433 mg), a procedure as in Example 36 was performed to give the title compound as pale-purple crystals (yield 186 mg, 68%).

출처 및 근거

ORD 기록
ord-f966d1dcaa354d3d9c3bcb083e1943db
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048909B2

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