Sodium borohydride → HCID 66924845, 화합물

HRID 554419노트

반응식

[Cl:1][C:2]1[C:3]([CH:23]=O)=[C:4]([CH3:22])[N:5]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.CO.[CH3:27][NH2:28].[BH4-].[Na+]>>[ClH:1].[Cl:1][C:2]1[C:3]([CH2:23][NH:28][CH3:27])=[C:4]([CH3:22])[N:5]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

반응물 3

HCID 4311764Sodium borohydride

HCID 57454252Monomethylamine methanol

HCID 86620751HCID 86620751, 화합물

생성물 1

HCID 66924845HCID 66924845, 화합물수율 84.9%

실험 절차

Using 4-chloro-2-methyl-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde (301 mg), 40% methylamine methanol solution (195 mg) and sodium borohydride (106 mg), a procedure as in Example 9 was performed. Recrystallization from a mixed solvent of ethyl acetate and ethanol gave the title compound as colorless crystals (yield 146 mg, 42%).

후처리

customRecrystallization from a mixed solvent of ethyl acetate and ethanol

출처 및 근거

ORD 기록: ord-7ea855457f63469fb3c9e99bd984bc32
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08048909B2

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