HCID 12660316, 화합물 → 2-Benzylphenol

HRID 554497

반응식

HRID 554497 반응식
Cl[C:2]1[CH:15]=[CH:14][C:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[OH:13])=[CH:4][CH:3]=1>CO.[OH-].[Pd+2].[OH-]>[CH2:6]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])[C:5]1[CH:4]=[CH:3][CH:2]=[CH:15][CH:14]=1

참가 물질

4

반응물 1

HCID 12660316HCID 12660316, 화합물

생성물 1

HCID 242162-Benzylphenol수율 67%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

To a solution of 2-(4-chlorobenzyl)phenol (618.5 mg, 2.83 mmol) in methanol (20 mL), a 20% palladium hydroxide catalyst (240 mg) was added. The mixture was stirred under a hydrogen atmosphere for three days, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)] to obtain the title compound (348.4 mg, 67%).

후처리

  1. filtrationthe catalyst was filtered off
  2. distillationThe solvent was distilled under reduced pressure
  3. customthe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)]

출처 및 근거

ORD 기록
ord-882e0f4fdfcf4a8086b0b4f0864124f9
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048897B2

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