Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 67459847, 화합물
반응식
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]=O)[N:6]=1.[CH3:9][O:10][C:11](=[O:32])[CH:12]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>O1CCCC1.O>[CH3:9][O:10][C:11](=[O:32])[CH:12]=[CH:7][C:5]1[N:6]=[C:2]([Br:1])[S:3][CH:4]=1참가 물질
5
실험 절차
Dissolve 2-bromothiazole-4-carbaldehyde (3.00 g, 15.62 mmol) in tetrahydrofuran (52 mL) and add methyl(triphenylphosphoranylidene)acetate (5.33 g. 15.62 mmol). Stir the mixture overnight at room temperature. Dilute the mixture with water and extract twice using diethyl ether. Dry the combined organics over sodium sulfate, filter, and concentrate. Purify via silica gel chromatography using a 0-30% gradient of EtOAc/hexanes to give 3.13 g (81%) of the title compound as a white solid.
후처리
- extractionextract twice using diethyl ether
- dry with materialDry the combined organics over sodium sulfate
- filtrationfilter
- concentrationconcentrate
- customPurify via silica gel chromatography
출처 및 근거
- ORD 기록
- ord-16f76a513b1c41c283f69bb220b0c352
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08049013B2
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