Lithium Hydroxide → 3-(2-Bromo-thiazol-4-yl)-acrylic acid
반응식
C[O:2][C:3](=[O:12])[CH:4]=[CH:5][C:6]1[N:7]=[C:8]([Br:11])[S:9][CH:10]=1.[OH-].[Li+]>O1CCCC1.O>[Br:11][C:8]1[S:9][CH:10]=[C:6]([CH:5]=[CH:4][C:3]([OH:12])=[O:2])[N:7]=1참가 물질
5
실험 절차
Dissolve 3-(2-bromo-thiazol-4-yl)-acrylic acid methyl ester (5.9 g, 23.78 mmol) in tetrahydrofuran (48 mL) and add a solution of lithium hydroxide (636 mg, 26.16 mmol) in water (10 mL). Stir the mixture overnight. Extract the mixture with ethyl acetate and wash twice with water. Acidify the aqueous layer with 1N HCl in water until the mixture is at pH 3-4. Filter the resulting white solid, then wash the solid with ethyl acetate, followed by diethyl ether and then water. Dry the white solid to give 5.05 g (91%) of the desired material.
후처리
- extractionExtract the mixture with ethyl acetate
- washwash twice with water
- filtrationFilter the resulting white solid
- washwash the solid with ethyl acetate
- customDry the white solid
출처 및 근거
- ORD 기록
- ord-0b75bd7791a246c08b3d3c0d8087ad7c
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08049013B2
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