Nitric Acid → 2-Amino-5-bromo-3-nitropyridine
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[N+:9]([O-])([OH:11])=[O:10].[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:1][C:2]1[C:7]([N+:9]([O-:11])=[O:10])=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
100 ml of concentrated sulfuric acid were added to 25.0 g of 2-amino-5-bromopyridine, and 8.9 ml of concentrated nitric acid were then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour. The mixture was then stirred at 60° C. for 30 minutes. At the end of this time, the reaction mixture was poured into ice-water and neutralized by the addition of an aqueous solution of sodium hydroxide. The crystals which precipitated were collected by filtration and washed with ethanol, to give 19.1 g of the title compound, melting at 180°-182° C.
후처리
- additionwere then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour
- customThe crystals which precipitated
- filtrationwere collected by filtration
- washwashed with ethanol
출처 및 근거
- ORD 기록
- ord-38508c88984e462da47b150b81e5377a
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05624935
반응 노트
불러오는 중…