Nitric Acid → 2-Amino-5-bromo-3-nitropyridine

HRID 55500

반응식

HRID 55500 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[N+:9]([O-])([OH:11])=[O:10].[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:1][C:2]1[C:7]([N+:9]([O-:11])=[O:10])=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 706222-Amino-5-bromopyridine

생성물 1

HCID 1388782-Amino-5-bromo-3-nitropyridine

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
60 °C

실험 절차

100 ml of concentrated sulfuric acid were added to 25.0 g of 2-amino-5-bromopyridine, and 8.9 ml of concentrated nitric acid were then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour. The mixture was then stirred at 60° C. for 30 minutes. At the end of this time, the reaction mixture was poured into ice-water and neutralized by the addition of an aqueous solution of sodium hydroxide. The crystals which precipitated were collected by filtration and washed with ethanol, to give 19.1 g of the title compound, melting at 180°-182° C.

후처리

  1. additionwere then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethanol

출처 및 근거

ORD 기록
ord-38508c88984e462da47b150b81e5377a
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624935

연결된 노트

불러오는 중…