Benzyl 4-Hydroxybenzoate → 4-({1-[(Tert-butoxy)carbonyl]pyrrolidin-3-yl}oxy)benzoic acid

HRID 555387노트

반응식

HRID 555387 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C([O:40][C:41](=[O:49])[C:42]1[CH:47]=[CH:46][C:45](O)=[CH:44][CH:43]=1)C1C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:45]2[CH:46]=[CH:47][C:42]([C:41]([OH:49])=[O:40])=[CH:43][CH:44]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 4

HCID 7180Benzyl 4-HydroxybenzoateHCID 11776TriphenylphosphineHCID 44169391-Boc-3-pyrrolidinolHCID 5462977Diethyl azodicarboxylate

생성물 1

HCID 227098074-({1-[(Tert-butoxy)carbonyl]pyrrolidin-3-yl}oxy)benzoic acid수율 69.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a stirred solution of 3-hydroxy-pyrrolidine-1-carboxylic acid t-butyl ester (3 g, 16.02 mmol) in dry THF (75 mL) was added triphenyl phosphine (4.62 g, 17.62 mmol) and 4-hydroxy-benzoic acid benzyl ester (4.02 g, 17.62 mmol). The reaction mixture was cooled to 0° C. and DEAD (2.78 mL, 17.62 mmol) was added dropwise over a period of 30 min. The reaction was gradually brought to room temperature and stirring continued for 16 hrs. The solvent was removed under vacuum and the residue purified by column chromatography (Flash 40) using a gradient of starting from EtOAc-heptane 1:20 to 1:5. Desired fractions were collected and the solvent evaporated in vacuo. The residue was dissolved in EtOH (80 mL) and 10% Pd/C (0.5 g) was added and the mixture was hydrogenated for 16 hrs. The mixture was filtered and the volatiles were evaporated in vacuo affording 3.4 g (69%) of 3-(4-carboxy-phenoxy)-pyrrolidine-1-carboxylic acid t-butyl ester as a solid.

후처리

  1. customwas gradually brought to room temperature
  2. customThe solvent was removed under vacuum
  3. customthe residue purified by column chromatography (Flash 40)
  4. customDesired fractions were collected
  5. customthe solvent evaporated in vacuo
  6. dissolutionThe residue was dissolved in EtOH (80 mL)
  7. addition10% Pd/C (0.5 g) was added
  8. waitthe mixture was hydrogenated for 16 hrs
  9. filtrationThe mixture was filtered
  10. customthe volatiles were evaporated in vacuo

출처 및 근거

ORD 기록
ord-dee2548d347f4a3abf9490eb41fb0846
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053447B2

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