1-Naphthyl Isothiocyanate → HCID 59857370, 화합물

HRID 555401

반응식

HRID 555401 반응식
[C:1]([C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[O:7][C:8]1[C:13]([NH2:14])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:19]1([N:29]=[C:30]=[S:31])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1>O1CCOCC1>[C:1]([C:5]1[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=1[O:7][C:8]1[C:13]([NH:14][C:30]([NH:29][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=[CH:21][CH:20]=2)=[S:31])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 110801-Naphthyl Isothiocyanate2회HCID 286054272-(2-tert-Butylphenoxy)pyridin-3-amine

생성물 1

HCID 59857370HCID 59857370, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
60 °C

실험 절차

A solution of 1b (40 mg, 0.17 mmol) and 1-naphtylisothiocyanate (34 mg, 0.18 mmol) in dioxane (2 mL) was heated at 60° C. for 6 h. More 1-naphtylisothiocyanate (34 mg, 0.18 mmol) was added and the mixture was heated at 60° C. for 8 days. The mixture was concentrated and the residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluent to afford 102a which was directly used in the next step. [M−H]−=426.18.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluent

출처 및 근거

ORD 기록
ord-ff6f066617144174b7fa06cc4e5ab556
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053450B2

연결된 노트

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