Bromoacetonitrile → [4-(3-Methoxy-propyl)-piperazin-1-yl]acetonitrile

HRID 555735

반응식

[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.Br[CH2:13][C:14]#[N:15]>>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([CH2:13][C:14]#[N:15])[CH2:10][CH2:11]1

참가 물질

반응물 2

HCID 11534Bromoacetonitrile

HCID 18225361-(3-Methoxypropyl)piperazine

생성물 1

HCID 63337188[4-(3-Methoxy-propyl)-piperazin-1-yl]acetonitrile

실험 절차

The title compound is synthesized by coupling of 1-(3-Methoxy-propyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=198.2: 1HNMR(DMSO-d6) 3.65 (s, 2H), 3.30 (s, 3H), 2.45-2.20 (m, 12H), 1.65-1.55 (m, 2H).

후처리

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

출처 및 근거

ORD 기록: ord-5a961d53f151413babf4cc3829fa4668
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08053457B2

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