Hydrochloric Acid → 4-(3-Chloropyrazin-2-yl)cyclohexanone
반응식
[Cl:1][C:2]1[C:7]([CH:8]2[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)=[N:6][CH:5]=[CH:4][N:3]=1.Cl>CC(C)=O>[Cl:1][C:2]1[C:7]([CH:8]2[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)=[N:6][CH:5]=[CH:4][N:3]=1참가 물질
4
실험 절차
2-Chloro-3-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazine (0.29 g, 1.14 mmol) was dissolved in acetone (8 mL) and 1M aqueous hydrochloric acid (1.0 mL, 1.0 mmol) was heated to 50° C. for 4 h, then cooled to RT. The acetone was removed under vacuum and the solution was then diluted with EtOAc. This mixture was transferred to a reparatory funnel and washed with sat. aqueous sodium bicarbonate (1×), brine (1×), dried over magnesium sulfate, filtered, and concentrated in vacuo. The resulting oil was purified by silica gel chromatography to give 4-(3-chloropyrazin-2-yl)cyclohexanone.
후처리
- customThe acetone was removed under vacuum
- additionthe solution was then diluted with EtOAc
- customThis mixture was transferred to a reparatory funnel
- washwashed with sat. aqueous sodium bicarbonate (1×), brine (1×)
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resulting oil was purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-fa48626777044d46b1f8c2dd05495b87
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08053438B2
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