1,3-Dibromopropane → N-[3-(3-Bromo-propoxy)-phenyl]-acetamide
반응식
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[Br:18][CH2:19][CH2:20][CH2:21]Br>ClCCl>[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[O:11][CH2:21][CH2:20][CH2:19][Br:18])(=[O:3])[CH3:2]참가 물질
5
실험 절차
To 3-acetamidophenol (15.1 g) in dichloromethane (500 ml, dry) was added potassium carbonate (20 g) and then 1,3-dibromopropane (30 g). The resulting mixture was heated at reflux for 6 hours and then overnight at room temperature. After an additional 24 hours, the reaction was complete. Solids were filtered from the reaction mixture, and the solution was concentrated to an oil, which was purified to yield 3-(3-acetamidophenoxy)propyl bromide, 13.2 g.
후처리
- temperatureThe resulting mixture was heated
- temperatureat reflux for 6 hours
- customovernight
- customat room temperature
- filtrationSolids were filtered from the reaction mixture
- concentrationthe solution was concentrated to an oil, which
- customwas purified
출처 및 근거
- ORD 기록
- ord-1cd804972d384cae9a5d08e029bf40a5
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05624927
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