Sodium Hydroxide → HCID 59703554, 화합물

HRID 556474노트

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HRID 556474 반응식
C[O:2][C:3]([CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:14][CH3:15])=[CH:10][CH:11]=2)[N:6]1[C:16]1([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=2)[C:24]2[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=2)[NH:18][C:17]1=[O:26])=[O:4].[OH-].[Na+]>CO.O>[Cl:25][C:21]1[CH:20]=[C:19]2[C:24]([C:16]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[CH:29]=3)([N:6]3[C:7]4[C:12](=[CH:11][CH:10]=[C:9]([O:14][CH3:15])[CH:8]=4)[CH2:13][CH:5]3[C:3]([OH:4])=[O:2])[C:17](=[O:26])[NH:18]2)=[CH:23][CH:22]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 66992271Rac-6'-chloro-3'-(3-chloro-benzyl)-6-methoxy-2'-oxo-2,3,2',3'-tetrahydro-1'h-[1,3']biindolyl-2-carboxylic acid methyl ester

생성물 1

HCID 59703554HCID 59703554, 화합물수율 103.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A mixture of rac-6′-Chloro-3′-(3-chloro-benzyl)-6-methoxy-2′-oxo-2,3,2′,3′-tetrahydro-1′H-[1,3′]biindolyl-2-carboxylic acid methyl ester (250 mg, 0.5 mmol), NaOH (40 mg, 1.0 mmol) in methanol (4 mL) and water (2 mL) was heated to reflux for 3 hr. Then the mixture was concentrated in vacuo to remove methanol. Water (10 mL) was added to the residue. The resulting mixture was acidified with acetic acid, extracted with ethyl acetate. The organic layer was washed with water, dried with Na2SO4, concentrated in vacuo to give 250 mg rac-6′-Chloro-3′-(3-chloro-benzyl)-6-methoxy-2′-oxo-2,3,2′,3′-tetrahydro-1′H-[1,3′]biindolyl-2-carboxylic acid. MS: [M−H]−=481

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 3 hr
  3. concentrationThen the mixture was concentrated in vacuo
  4. customto remove methanol
  5. additionWater (10 mL) was added to the residue
  6. extractionextracted with ethyl acetate
  7. washThe organic layer was washed with water
  8. dry with materialdried with Na2SO4
  9. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c771ae2a6cfa41a89e6c52be26b7ef20
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058269B2

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