Cyclohexylamine → HCID 59639572, 화합물

HRID 556640노트

반응식

HRID 556640 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:12]2[N:13]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:30])[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

참가 물질

3

반응물 2

HCID 7965CyclohexylamineHCID 59639608HCID 59639608, 화합물

생성물 1

HCID 59639572HCID 59639572, 화합물수율 48.1%

실험 절차

Following the general procedure outlined in Example 126, the product of Example 121 (200 mg, 0.47 mmol), and cyclohexylamine (0.27 mL, 2.36 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 100 mg (48%). LC-MS: 443.4 (MH+, m/z), 2.79 (Rt, min).

후처리

  1. customto give the crude material, which
  2. customwas purified

출처 및 근거

ORD 기록
ord-6c70eb76a93945d2a8e7b72054a0834c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058282B2

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