Aluminum(III) Chloride → 1-(4-Chloro-2-hydroxyphenyl)ethanone

반응식

[OH:1][C:2]1[CH:7]=[C:6](OC(C(OCC)=O)(C)C)[CH:5]=[CH:4][C:3]=1[C:17](=[O:19])[CH3:18].[Cl-:20].[Al+3].[Cl-].[Cl-]>>[Cl:20][C:6]1[CH:5]=[CH:4][C:3]([C:17](=[O:19])[CH3:18])=[C:2]([OH:1])[CH:7]=1

참가 물질

반응물 2

HCID 6451240Aluminum(III) Chloride

HCID 577628812'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone2회

생성물 1

HCID 10515131-(4-Chloro-2-hydroxyphenyl)ethanone

반응 조건

온도: 200 °C

실험 절차

3-chlorophenyl acetate (starting material 2) was mixed with aluminium chloride (3 eq). The mixture was heated at 200° C. for 1 hour. The reaction medium was cooled to room temperature then poured in ice. The aqueous phase was extracted with methylene chloride which was dried on magnesium sulfate then vacuum evaporated.

후처리

temperatureThe reaction medium was cooled to room temperature
additionthen poured in ice
extractionThe aqueous phase was extracted with methylene chloride which
customwas dried on magnesium sulfate
customvacuum evaporated

출처 및 근거

ORD 기록: ord-5c461b7df70d40b1a5e16f14447e9a27
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08058308B2

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