Methyl iodide → 6,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

HRID 557129노트

반응식

HRID 557129 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]([CH3:15])[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:7][C:6]2=[S:22].[I:23][CH3:24]>>[I-:23].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N+:9]([CH3:15])=[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:7]=[C:6]2[S:22][CH3:24]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 866355306,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione

생성물 1

HCID 669913456,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

실험 절차

1.00 g (3.20 mmol) 6,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione was slowly added to 5 ml (80 mmol) iodomethane at 0° C. and stirred for 1 h at room temperature. The solution was filtrated and the residue washed with ethyl ether and dichloromethane.

후처리

  1. filtrationThe solution was filtrated
  2. washthe residue washed with ethyl ether and dichloromethane

출처 및 근거

ORD 기록
ord-29a46963b21a4491bf07eb420f74de6a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058431B2

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