Chloroform → 2-(4-Dimethylamino-butyl)-5,6-dimethoxy-1-methyl-1H-quinazoline-4-one

반응식

[CH3:1][N:2]([CH:4]([CH2:8][CH2:9][CH3:10])C(O)=O)[CH3:3].S(Cl)(Cl)=O.[CH3:15][NH:16][C:17]1[C:22]([C:23]([NH2:25])=[O:24])=[C:21]([O:26][CH3:27])[C:20]([O:28][CH3:29])=[CH:19][CH:18]=1.Cl[CH:31](Cl)Cl>>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:8][CH2:9][CH2:10][C:15]1[N:16]([CH3:31])[C:17]2[C:22]([C:23](=[O:24])[N:25]=1)=[C:21]([O:26][CH3:27])[C:20]([O:28][CH3:29])=[CH:19][CH:18]=2

참가 물질

반응물 4

HCID 6212Chloroform

HCID 24386Thionyl Chloride

HCID 178834622-(Dimethylamino)pentanoic acid

HCID 669909586-Methylamino-2,3-dimethoxybenzamide

생성물 1

HCID 669913772-(4-Dimethylamino-butyl)-5,6-dimethoxy-1-methyl-1H-quinazoline-4-one

반응 조건

온도: 57.5 °C

실험 절차

3.80 g (20.9 mmol) Dimethylamino-pentanoic acid were added to 25 ml thionyl chloride and stirred for 90 min. at 55-60° C. The remaining thionyl chloride was distilled in vacuum and the residue was added to a solution of 2.00 g (11.1 mmol) 6-methylamino-2,3-dimethoxybenzamide dissolved in 30 ml trichloromethane at 0° C. The mixture was boiled for 2 h and stirred overnight at room temperature. After filtration the residue was dissolved in trichloromethane and saturated sodium bicarbonate solution. The organic solution was dried over magnesium sulfate and evaporated under vacuum.