Ethyl Acetoacetate → Ethyl 2-[(6-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate

반응식

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH:12]=O)[CH:11]=1)[O:8][C:7]([CH3:14])=[CH:6][C:5]2=[O:15].[C:16]([O:22][CH2:23][CH3:24])(=[O:21])[CH2:17][C:18]([CH3:20])=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH:12]=[C:17]([C:18](=[O:19])[CH3:20])[C:16]([O:22][CH2:23][CH3:24])=[O:21])[CH:11]=1)[O:8][C:7]([CH3:14])=[CH:6][C:5]2=[O:15]

참가 물질

반응물 2

HCID 8868Ethyl Acetoacetate

HCID 578286506-Fluoro-2-methyl-4-oxo-4H-1-benzopyran-8-carbaldehyde

생성물 1

HCID 66991191Ethyl 2-[(6-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]-3-oxobutanoate

실험 절차

The title compound is prepared in analogy to example 25 (stage 25a) starting from 6-fluoro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde (2.18 g, 10.62 mmol) and ethyl acetoacetate (1.33 g, 10.62 mmol). 3.30 g (98% of theory) of the title compound are obtained as an E/Z isomer mixture.

후처리

customThe title compound is prepared in analogy to example 25 (stage 25a)

출처 및 근거

ORD 기록: ord-9ce9a6eda12745f59bfd59ad0e46452c
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08058447B2

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