Methyl morpholine oxide → 2-Methyl-5-nitro-4-oxo-4H-1-benzopyran-8-carbaldehyde

HRID 557427노트

반응식

HRID 557427 반응식
Br[CH:2](Br)[C:3]1[CH:4]=[CH:5][C:6]([N+:15]([O-:17])=[O:16])=[C:7]2[C:12]=1[O:11][C:10]([CH3:13])=[CH:9][C:8]2=[O:14].C[N+]1([O-])CC[O:23]CC1>C(#N)C>[CH3:13][C:10]1[O:11][C:12]2[C:7]([C:8](=[O:14])[CH:9]=1)=[C:6]([N+:15]([O-:17])=[O:16])[CH:5]=[CH:4][C:3]=2[CH:2]=[O:23]

참가 물질

4

반응물 2

HCID 82029Methyl morpholine oxideHCID 578286378-(Dibromomethyl)-2-methyl-5-nitro-4H-1-benzopyran-4-one

생성물 1

HCID 578286522-Methyl-5-nitro-4-oxo-4H-1-benzopyran-8-carbaldehyde

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

175 mg (0.47 mmol) of 8-(dibromomethyl)-2-methyl-5-nitro-4H-chromen-4-one are heated under reflux with 151 mg (1.29 mmol) of N-methylmorpholine N-oxide with the addition of molecular sieves in 15 ml of acetonitrile overnight. After filtration through kieselguhr, the solvent is removed in vacuo, and the residue is purified by preparative HPLC. 23 mg (24% of theory) of the title compound are obtained.

후처리

  1. filtrationAfter filtration through kieselguhr
  2. customthe solvent is removed in vacuo
  3. customthe residue is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-94997dea25a14cd89bbdf53f3e0bc59d
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058447B2

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