Methyl morpholine oxide → 8-Formyl-2-methyl-4-oxo-4H-1-benzopyran-5-carbonitrile
반응식
Br[CH:2](Br)[C:3]1[C:12]2[O:11][C:10]([CH3:13])=[CH:9][C:8](=[O:14])[C:7]=2[C:6]([C:15]#[N:16])=[CH:5][CH:4]=1.C[N+]1([O-])CC[O:22]CC1>C(#N)C>[CH:2]([C:3]1[C:12]2[O:11][C:10]([CH3:13])=[CH:9][C:8](=[O:14])[C:7]=2[C:6]([C:15]#[N:16])=[CH:5][CH:4]=1)=[O:22]참가 물질
4
실험 절차
260 mg (0.72 mmol) of 8-(dibromomethyl)-2-methyl-4-oxo-4H-chromene-5-carbonitrile are heated with 187 mg (1.6 mmol) of N-methylmorpholine N-oxide with the addition of molecular sieves in 15 ml of acetonitrile under reflux overnight. After filtration through kieselguhr, the solvent is removed in vacuo, and the residue is purified by preparative HPLC. 23 mg (15% of theory) of the title compound are obtained.
후처리
- temperatureunder reflux overnight
- filtrationAfter filtration through kieselguhr
- customthe solvent is removed in vacuo
- customthe residue is purified by preparative HPLC
출처 및 근거
- ORD 기록
- ord-ddce7f24a8f542deb19af123e9a9deb8
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08058447B2
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