참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 2-Bromonaphthalene | HCID 11372 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Nitrobenzene | HCID 7416 | — |
| 생성물 | 1-(6-Bromonaphthalen-2-yl)ethanone | HCID 12433082 | 45.2% |
반응 단계
A mixture of 2-bromonaphthalene (41.4 g, 200 mmol), acetyl chloride (11.3 mL, 160 mmol), nitrobenzene (250 mL) and AlCl3 (28 g, 210 mmol) was stirred for 4 hours at 100° C. (oil bath temperature). The resulting reaction mixture was cooled, poured onto ice/water (100 mL) and filtered. The filtrate was washed with water (100 mL). The solvent (nitrobenzene) was removed by distillation. The resulting residue was crystallized from hexane to afford 18 g of desired product (36% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09433609B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-b60eeb7c6fab4f59b90f53646531cecb |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
