Dimethylformamide → 4-Bromo-2-methoxybenzoyl chloride

HRID 557670노트

반응식

HRID 557670 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([O:11][CH3:12])[CH:3]=1.CN(C=O)C.S(Cl)([Cl:20])=O>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:20])=[O:7])=[C:4]([O:11][CH3:12])[CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 134507554-Bromo-2-methoxybenzoic acid

생성물 1

HCID 223467824-Bromo-2-methoxybenzoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
55 °C

실험 절차

To a suspension of 4-bromo-2-methoxybenzoic acid (2.5 g, 11.04 mmol) in CHCl3 (20 mL) was added DMF (catalytic) and thionyl chloride (1.6 mL, 22.08 mmol). The reaction was stirred at 55° C. for 1 hour and then concentrated to dryness to give the title compound.

후처리

  1. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-67b277e335884ebdaa425a295cfd4436
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058300B2

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