Hydrochloric Acid → 1-(3,5-Dibromophenyl)ethanone

HRID 557673

반응식

HRID 557673 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.C[Li].[CH3:14]COC(C)=O.Cl>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:14])[CH:3]=[C:2]([Br:1])[CH:10]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 12063Benzoic acid, 3,5-dibromo-HCID 178418348HCID 178418348, 화합물

생성물 1

HCID 6218251-(3,5-Dibromophenyl)ethanone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.

후처리

  1. customThe crude material was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-39c48f6d7e864b28b0186d9de9d4f0ef
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058300B2

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