Pyridine → BROMO-ACETIC ACID 2-FORMYL-PHENYL ESTER

HRID 558031노트

반응식

HRID 558031 반응식
[CH:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].N1C=CC=CC=1.[Br:16][CH2:17][C:18](Br)=[O:19]>ClCCl>[CH:1]([C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[O:4][C:18](=[O:19])[CH2:17][Br:16])=[O:9]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6998SalicylaldehydeHCID 61147Bromoacetyl bromide

생성물 1

HCID 11470550BROMO-ACETIC ACID 2-FORMYL-PHENYL ESTER수율 60.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of Salicylaldehyde (50 grams) and pyridine (48.5 grams) in dichloromethane (500 ml) maintained at 0-5° C. under nitrogen atmosphere was added dropwise bromoacetyl bromide (210.6 grams). The reaction mixture was stirred for one hour at the same temperature. The reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution, dried over sodium sulphate followed by distillation of solvent under reduced pressure to get 60.0 grams of bromo-acetic acid 2-formyl-phenyl ester.

후처리

  1. washThe reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution
  2. dry with materialdried over sodium sulphate
  3. distillationfollowed by distillation of solvent under reduced pressure

출처 및 근거

ORD 기록
ord-784a51c58e76457eb6f4b0dd73268bf6
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08062653B2

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