Hydrochloric Acid → 2-(2-Bromo-4-chlorophenyl)-2-fluoroethanamine, hydrochloride

HRID 558113노트

반응식

HRID 558113 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([F:12])[C:10]#[N:11].C(O)C.Cl>C1COCC1>[ClH:8].[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([F:12])[CH2:10][NH2:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 574450602-(2-Bromo-4-chlorophenyl)-2-fluoroacetonitrile

생성물 1

HCID 1317292842-(2-Bromo-4-chlorophenyl)-2-fluoroethanamine, hydrochloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

Dissolve 2-(2-bromo-4-chlorophenyl)-2-fluoroacetonitrile (2.45 g, 9.86 mmol) in THF (50 mL). Cool the mixture to 0° C., then add BH3-THF complex (1 N, 20 mL, 20 mmol), and stir overnight. Add ethanol (5 mL) and then adjust to acidic with an ethanolic HCl solution. After removing the solvent, add DCM (20 mL) to the solid. Filter and wash with DCM, and dry to give the title compound as the HCl salt. MS (ES) m/z 254 [M+1]+.

후처리

  1. customAfter removing the solvent
  2. additionadd DCM (20 mL) to the solid
  3. filtrationFilter
  4. washwash with DCM
  5. customdry

출처 및 근거

ORD 기록
ord-f3dd02536dd14319a89d307f450df901
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063035B2

반응 노트

불러오는 중…